Reaction Details Report a problem with these data
Target
Beta-1 adrenergic receptor
Ligand
BDBM50557257
Substrate
n/a
Meas. Tech.
ChEMBL_2058442 (CHEMBL4713443)
Ki
800±n/a nM
Citation
 Lin, H; Sharabi, K; Lin, L; Ruiz, C; Zhu, D; Cameron, MD; Novick, SJ; Griffin, PR; Puigserver, P; Kamenecka, TM Structure-Activity Relationship and Biological Investigation of SR18292 ( J Med Chem 64:980-990 (2021) [PubMed]  Article 
Target
Name:
Beta-1 adrenergic receptor
Synonyms:
ADRB1 | ADRB1R | ADRB1_HUMAN | B1AR | Beta-1 adrenoceptor | Beta-1 adrenoreceptor | adrenergic Beta1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
51338.40
Organism:
Homo sapiens (Human)
Description:
P08588
Residue:
477
Sequence:
MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQGLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
  
Inhibitor
Name:
BDBM50557257
Synonyms:
CHEMBL4789047
Type:
Small organic molecule
Emp. Form.:
C23H30N2O2
Mol. Mass.:
366.4965
SMILES:
Cc1ccc(CN(CC(O)COc2cccc3[nH]ccc23)C(C)(C)C)cc1
Structure:
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