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Target
Voltage-dependent calcium channel subunit alpha-2/delta-1
Ligand
BDBM50557453
Substrate
n/a
Meas. Tech.
ChEMBL_2059155 (CHEMBL4714156)
Ki
208±n/a nM
Citation
 Díaz, JL; Cuevas, F; Pazos, G; Álvarez-Bercedo, P; Oliva, AI; Sarmentero, MÁ; Font, D; Jiménez-Aquino, A; Morón, M; Port, A; Pascual, R; Dordal, A; Portillo-Salido, E; Reinoso, RF; Vela, JM; Almansa, C Bicyclic Diazepinones as Dual Ligands of the ?2?-1 Subunit of Voltage-Gated Calcium Channels and the Norepinephrine Transporter. J Med Chem 64:2167-2185 (2021) [PubMed]  Article 
Target
Name:
Voltage-dependent calcium channel subunit alpha-2/delta-1
Synonyms:
CA2D1_HUMAN | CACNA2D1 | CACNL2A | CCHL2A | MHS3 | Voltage-dependent calcium channel subunit alpha-2-1 | Voltage-dependent calcium channel subunit delta-1 | Voltage-gated calcium channel | Voltage-gated calcium channel alpha2/delta subunit 1 | Voltage-gated calcium channel subunit alpha-2/delta-1
Type:
Enzyme
Mol. Mass.:
124544.88
Organism:
Homo sapiens (Human)
Description:
P54289
Residue:
1103
Sequence:
MAAGCLLALTLTLFQSLLIGPSSEEPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDIYEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASNEVVYYNAKDDLDPEKNDSEPGSQRIKPVFIEDANFGRQISYQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDVSCFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRANCNKIIMLFTDGGEERAQEIFNKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNITGQFENKTNLKNQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKPIGVGIPTINLRKRRPNIQNPKSQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAKLEETITQARYSETLKPDNFEESGYTFIAPRDYCNDLKISDNNTEFLLNFNEFIDRKTPNNPSCNADLINRVLLDAGFTNELVQNYWSKQKNIKGVKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYFNKSGPGAYESGIMVSKAVEIYIQGKLLKPAVVGIKIDVNSWIENFTKTSIRDPCAGPVCDCKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSLMRHLVNISVYAFNKSYDYQSVCEPGAAPKQGAGHRSAYVPSVADILQIGWWATAAAWSILQQFLLSLTFPRLLEAVEMEDDDFTASLSKQSCITEQTQYFFDNDSKSFSGVLDCGNCSRIFHGEKLMNTNLIFIMVESKGTCPCDTRLLIQAEQTSDGPNPCDMVKQPRYRKGPDVCFDNNVLEDYTDCGGVSGLNPSLWYIIGIQFLLLWLVSGSTHRLL
  
Inhibitor
Name:
BDBM50557453
Synonyms:
CHEMBL4747442 | US11401270, Example 73
Type:
Small organic molecule
Emp. Form.:
C23H26N4O2S
Mol. Mass.:
422.543
SMILES:
CNCCC(Oc1cccc(c1)N1CCN(C)c2cnccc2C1=O)c1cccs1
Structure:
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