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Target
Alpha-1B adrenergic receptor
Ligand
BDBM50022722
Substrate
n/a
Meas. Tech.
ChEMBL_34311 (CHEMBL648096)
Ki
9600±n/a nM
Citation
 Altenbach, RJ; Khilevich, A; Meyer, MD; Buckner, SA; Milicic, I; Daza, AV; Brune, ME; O'Neill, AB; Gauvin, DM; Cain, JC; Nakane, M; Holladay, MW; Williams, M; Brioni, JD; Sullivan, JP N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine. J Med Chem 45:4395-7 (2002) [PubMed]  Article 
Target
Name:
Alpha-1B adrenergic receptor
Synonyms:
ADA1B_HUMAN | ADRA1B | Adrenergic alpha1B | Adrenergic receptor | Adrenergic receptor alpha | Alpha 1B-adrenoceptor | Alpha 1B-adrenoreceptor | Alpha-1B adrenergic receptor
Type:
Enzyme
Mol. Mass.:
56862.13
Organism:
Homo sapiens (Human)
Description:
P35368
Residue:
520
Sequence:
MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRGRRRRRRRRRLGGCAYTYRPWTRGGSLERSQSRKDSLDDSGSCLSGSQRTLPSASPSPGYLGRGAPPPVELCAFPEWKAPGALLSLPAPEPPGRRGRHDSGPLFTFKLLTEPESPGTDGGASNGGCEAAADVANGQPGFKSNMPLAPGQF
  
Inhibitor
Name:
BDBM50022722
Synonyms:
(+)2-Amino-1-phenyl-propan-1-ol | (1R, 2R)-2-Amino-1-phenyl-propan-1-ol | (1R, 2S)-2-Amino-1-phenyl-propan-1-ol | (1S, 2R)-2-Amino-1-phenyl-propan-1-ol | (1S, 2S)-2-Amino-1-phenyl-propan-1-ol | 2-Amino-1-phenyl-propan-1-ol | Biphetap | Bromanate | Bromatapp | CHEMBL136560 | Codamine | Contac | Demazin | Dimetane-DC | Dimetapp | Drize | Hycomine | Norephedrine, (+) | Norephedrine, (-) | Ornade | PHENYLPROPANOLAMINE | Pseudonorephedrine, (+) [cathine, (+)] | Pseudonorephedrine, (-) [cathine, (-)] | Tavist-D | Triaminic-12
Type:
Small organic molecule
Emp. Form.:
C9H13NO
Mol. Mass.:
151.2056
SMILES:
CC(N)C(O)c1ccccc1
Structure:
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