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Target
Dual specificity protein kinase CLK3
Ligand
BDBM50434353
Substrate
n/a
Meas. Tech.
ChEMBL_2064265 (CHEMBL4719518)
IC50
>10000±n/a nM
Citation
 Chaikuad, A; Diharce, J; Schröder, M; Foucourt, A; Leblond, B; Casagrande, AS; Désiré, L; Bonnet, P; Knapp, S; Besson, T An Unusual Binding Model of the Methyl 9-Anilinothiazolo[5,4-f] quinazoline-2-carbimidates (EHT 1610 and EHT 5372) Confers High Selectivity for Dual-Specificity Tyrosine Phosphorylation-Regulated Kinases. J Med Chem 59:10315-10321 (2016) [PubMed]  Article 
Target
Name:
Dual specificity protein kinase CLK3
Synonyms:
CDC2-like kinase 3 (CLK3) | CLK3 | CLK3_HUMAN | Dual specificity protein kinase CLK3
Type:
Protein
Mol. Mass.:
73570.11
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
638
Sequence:
MPVLSARRRELADHAGSGRRSGPSPTARSGPHLSALRAQPARAAHLSGRGTYVRRDTAGGGPGQARPLGPPGTSLLGRGARRSGEGWCPGAFESGARAARPPSRVEPRLATAASREGAGLPRAEVAAGSGRGARSGEWGLAAAGAWETMHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR
  
Inhibitor
Name:
BDBM50434353
Synonyms:
CHEMBL2386747 | US9446044, 72
Type:
Small organic molecule
Emp. Form.:
C17H11Cl2N5OS
Mol. Mass.:
404.273
SMILES:
COC(=N)c1nc2ccc3ncnc(Nc4ccc(Cl)cc4Cl)c3c2s1
Structure:
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