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Target
Testis-specific serine/threonine-protein kinase 6
Ligand
BDBM2579
Substrate
n/a
Meas. Tech.
ChEMBL_2065295 (CHEMBL4720548)
IC50
112±n/a nM
Citation
 Hou, W; Ren, Y; Zhang, Z; Sun, H; Ma, Y; Yan, B Novel quinazoline derivatives bearing various 6-benzamide moieties as highly selective and potent EGFR inhibitors. Bioorg Med Chem 26:1740-1750 (2018) [PubMed]  Article 
Target
Name:
Testis-specific serine/threonine-protein kinase 6
Synonyms:
CT72 | Cancer/testis antigen 72 | Serine/threonine-protein kinase SSTK | Small serine/threonine kinase | TSK-6 | TSSK-6 | Testis-specific kinase 6 | Testis-specific serine/threonine-protein kinase 6 | TSSK6_HUMAN | TSSK6 | SSTK
Type:
PROTEIN
Mol. Mass.:
30343.80
Organism:
Human
Description:
ChEMBL_109904
Residue:
273
Sequence:
MSGDKLLSELGYKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRELSILRGVRHPHIVHVFEFIEVCNGKLYIVMEAAATDLLQAVQRNGRIPGVQARDLFAQIAGAVRYLHDHHLVHRDLKCENVLLSPDERRVKLTDFGFGRQAHGYPDLSTTYCGSAAYASPEVLLGIPYDPKKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQKRGVLYPEGLELSERCKALIAELLQFSPSARPSAGQVARNCWLRAGDSG
  
Inhibitor
Name:
BDBM2579
Synonyms:
CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 | (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one | Staurosporine | US9206188, Staurosporine | US9226923, Staurosporine | US20240002365, Compound staurosporine | US11958831, Example Staurosporine | US20240254124, Compound Staurosporine | US20240309004, Compound STAUROSPORINE | US12350272, Compound Staurosporine | US12398142, Compound Staurosporine | US12410173, Compound Staurosporine
Type:
Small organic molecule
Emp. Form.:
C28H26N4O3
Mol. Mass.:
466.20
SMILES:
C[C@@]12[C@@H]([C@@H](C[C@@H](O1)n3c4ccccc4c5c3c6n2c7ccccc7c6c8c5C(=O)NC8)NC)OC
Structure:
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