Reaction Details Report a problem with these data
Target
P2Y purinoceptor 2
Ligand
BDBM50558924
Substrate
n/a
Meas. Tech.
ChEMBL_2067087 (CHEMBL4722340)
IC50
5550±n/a nM
Citation
 Pillaiyar, T; Funke, M; Al-Hroub, H; Weyler, S; Ivanova, S; Schlegel, J; Abdelrahman, A; Müller, CE Design, synthesis and biological evaluation of suramin-derived dual antagonists of the proinflammatory G protein-coupled receptors P2Y Eur J Med Chem 186:0 (2020) [PubMed]  Article 
Target
Name:
P2Y purinoceptor 2
Synonyms:
ATP receptor | P2RU1 | P2RY2 | P2RY2_HUMAN | P2U purinoceptor 1 | P2U1 | P2Y purinoceptor 2 | P2Y2 | Purinergic receptor | Purinergic receptor P2Y2
Type:
PROTEIN
Mol. Mass.:
42299.21
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1455361
Residue:
377
Sequence:
MAADLGPWNDTINGTWDGDELGYRCRFNEDFKYVLLPVSYGVVCVPGLCLNAVALYIFLCRLKTWNASTTYMFHLAVSDALYAASLPLLVYYYARGDHWPFSTVLCKLVRFLFYTNLYCSILFLTCISVHRCLGVLRPLRSLRWGRARYARRVAGAVWVLVLACQAPVLYFVTTSARGGRVTCHDTSAPELFSRFVAYSSVMLGLLFAVPFAVILVCYVLMARRLLKPAYGTSGGLPRAKRKSVRTIAVVLAVFALCFLPFHVTRTLYYSFRSLDLSCHTLNAINMAYKVTRPLASANSCLDPVLYFLAGQRLVRFARDAKPPTGPSPATPARRRLGLRRSDRTDMQRIEDVLGSSEDSRRTESTPAGSENTKDIRL
  
Inhibitor
Name:
BDBM50558924
Synonyms:
CHEMBL4741688
Type:
Small organic molecule
Emp. Form.:
C19H13FN2O6S
Mol. Mass.:
416.38
SMILES:
[O-][N+](=O)c1cccc(OS(=O)(=O)c2ccc(NC(=O)c3cccc(F)c3)cc2)c1
Structure:
Search PDB for entries with ligand similarity: