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Target
Cytochrome c oxidase subunit 2
Ligand
BDBM50558937
Substrate
n/a
Meas. Tech.
ChEMBL_2067170 (CHEMBL4722423)
IC50
4230±n/a nM
Citation
 Jan, MS; Ahmad, S; Hussain, F; Ahmad, A; Mahmood, F; Rashid, U; Abid, OU; Ullah, F; Ayaz, M; Sadiq, A Design, synthesis, in-vitro, in-vivo and in-silico studies of pyrrolidine-2,5-dione derivatives as multitarget anti-inflammatory agents. Eur J Med Chem 186:0 (2020) [PubMed]  Article 
Target
Name:
Cytochrome c oxidase subunit 2
Synonyms:
COII | COX2 | COX2_HUMAN | COXII | MT-CO2 | MTCO2
Type:
PROTEIN
Mol. Mass.:
25555.66
Organism:
Homo sapiens (Human)
Description:
ChEMBL_530099
Residue:
227
Sequence:
MAHAAQVGLQDATSPIMEELITFHDHALMIIFLICFLVLYALFLTLTTKLTNTNISDAQEMETVWTILPAIILVLIALPSLRILYMTDEVNDPSLTIKSIGHQWYWTYEYTDYGGLIFNSYMLPPLFLEPGDLRLLDVDNRVVLPIEAPIRMMITSQDVLHSWAVPTLGLKTDAIPGRLNQTTFTATRPGVYYGQCSEICGANHSFMPIVLELIPLKIFEMGPVFTL
  
Inhibitor
Name:
BDBM50558937
Synonyms:
CHEMBL4779865
Type:
Small organic molecule
Emp. Form.:
C18H16N2O5S
Mol. Mass.:
372.395
SMILES:
NS(=O)(=O)c1ccc(cc1)N1C(=O)CC(CC(=O)c2ccccc2)C1=O
Structure:
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