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Target
Reverse transcriptase/RNaseH
Ligand
BDBM50121350
Substrate
n/a
Meas. Tech.
ChEMBL_195204 (CHEMBL798996)
IC50
4120±n/a nM
Citation
 Barreca, ML; Balzarini, J; Chimirri, A; De Clercq, E; De Luca, L; Höltje, HD; Höltje, M; Monforte, AM; Monforte, P; Pannecouque, C; Rao, A; Zappalà, M Design, synthesis, structure-activity relationships, and molecular modeling studies of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV agents. J Med Chem 45:5410-3 (2002) [PubMed]  Article 
Target
Name:
Reverse transcriptase/RNaseH
Synonyms:
HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH
Type:
PROTEIN
Mol. Mass.:
65229.15
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_1473730
Residue:
566
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRKVLFLDGID
  
Inhibitor
Name:
BDBM50121350
Synonyms:
2-(2-Chloro-6-fluoro-phenyl)-3-(4-methyl-pyridin-2-yl)-thiazolidin-4-one | 2-(2-Chloro-6-fluorophenyl)-3-(4-methylpyridin-2-yl)-l,3-thiazolidin-4-one | 2-(2-chloro-6-fluorophenyl)-3-(4-methylpyridin-2-yl)thiazolidin-4-one | CHEMBL151152
Type:
Small organic molecule
Emp. Form.:
C15H12ClFN2OS
Mol. Mass.:
322.785
SMILES:
Cc1ccnc(c1)N1C(SCC1=O)c1c(F)cccc1Cl
Structure:
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