Reaction Details Report a problem with these data
Target
Peptide deformylase, mitochondrial
Ligand
BDBM50121442
Substrate
n/a
Meas. Tech.
ChEMBL_154183 (CHEMBL761653)
Ki
2500±n/a nM
Citation
 Smith, HK; Beckett, RP; Clements, JM; Doel, S; East, SP; Launchbury, SB; Pratt, LM; Spavold, ZM; Thomas, W; Todd, RS; Whittaker, M Structure-activity relationships of the peptide deformylase inhibitor BB-3497: modification of the metal binding group. Bioorg Med Chem Lett 12:3595-9 (2002) [PubMed]  Article 
Target
Name:
Peptide deformylase, mitochondrial
Synonyms:
DEFM_HUMAN | PDF | PDF1A | Peptide deformylase mitochondrial | Peptide deformylase, mitochondrial | Polypeptide deformylase
Type:
PROTEIN
Mol. Mass.:
27023.25
Organism:
Homo sapiens (Human)
Description:
ChEMBL_154318
Residue:
243
Sequence:
MARLWGALSLWPLWAAVPWGGAAAVGVRACSSTAAPDGVEGPALRRSYWRHLRRLVLGPPEPPFSHVCQVGDPVLRGVAAPVERAQLGGPELQRLTQRLVQVMRRRRCVGLSAPQLGVPRQVLALELPEALCRECPPRQRALRQMEPFPLRVFVNPSLRVLDSRLVTFPEGCESVAGFLACVPRFQAVQISGLDPNGEQVVWQASGWAARIIQHEMDHLQGCLFIDKMDSRTFTNVYWMKVND
  
Inhibitor
Name:
BDBM50121442
Synonyms:
5-Guanidino-2-(2-mercaptomethyl-hexanoylamino)-pentanoic acid methyl ester; TFA | CHEMBL122127
Type:
Small organic molecule
Emp. Form.:
C14H28N4O3S
Mol. Mass.:
332.462
SMILES:
CCCCC(CS)C(=O)NC(CCCNC(N)=N)C(=O)OC
Structure:
Search PDB for entries with ligand similarity: