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Target
Puromycin-sensitive aminopeptidase
Ligand
BDBM50121709
Substrate
n/a
Meas. Tech.
ChEBML_160080
IC50
3800±n/a nM
Citation
 Kakuta, H; Koiso, Y; Nagasawa, K; Hashimoto, Y Fluorescent bioprobes for visualization of puromycin-sensitive aminopeptidase in living cells. Bioorg Med Chem Lett 13:83-6 (2002) [PubMed]  Article 
Target
Name:
Puromycin-sensitive aminopeptidase
Synonyms:
Aminopeptidase | NPEPPS | PSA | PSA_HUMAN
Type:
PROTEIN
Mol. Mass.:
103262.98
Organism:
Homo sapiens (Human)
Description:
ChEMBL_160080
Residue:
919
Sequence:
MWLAAAAPSLARRLLFLGPPPPPLLLLVFSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDIITASYAPEGDEEIHATGFNYQNEDEKVTLSFPSTLQTGTGTLKIDFVGELNDKMKGFYRSKYTTPSGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPDDENLVEVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGKFALEVAAKTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQELDALDNSHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAATEDLWESLENASGKPIAAVMNTWTKQMGFPLIYVEAEQVEDDRLLRLSQKKFCAGGSYVGEDCPQWMVPITISTSEDPNQAKLKILMDKPEMNVVLKNVKPDQWVKLNLGTVGFYRTQYSSAMLESLLPGIRDLSLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNLGILSTLLSHTDFYEEIQEFVKDVFSPIGERLGWDPKPGEGHLDALLRGLVLGKLGKAGHKATLEEARRRFKDHVEGKQILSADLRSPVYLTVLKHGDGTTLDIMLKLHKQADMQEEKNRIERVLGATLLPDLIQKVLTFALSEEVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEELYNRYQGGFLISRLIKLSVEGFAVDKMAGEVKAFFESHPAPSAERTIQQCCENILLNAAWLKRDAESIHQYLLQRKASPPTV
  
Inhibitor
Name:
BDBM50121709
Synonyms:
CHEMBL169458 | PAQ-22
Type:
Small organic molecule
Emp. Form.:
C18H18N2O2
Mol. Mass.:
294.3477
SMILES:
CCc1cccc(CC)c1-n1c(=O)[nH]c2ccccc2c1=O |(9.41,3.63,;9.41,2.09,;10.76,1.32,;12.09,2.09,;13.42,1.32,;13.42,-.23,;12.09,-.99,;12.07,-2.53,;13.4,-3.31,;10.76,-.22,;9.41,-.98,;9.41,-2.53,;10.74,-3.31,;8.06,-3.3,;6.73,-2.53,;5.4,-3.3,;4.07,-2.53,;4.07,-.98,;5.4,-.21,;6.73,-.98,;8.07,-.19,;8.07,1.35,)|
Structure:
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