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Target
Puromycin-sensitive aminopeptidase
Ligand
BDBM50121711
Substrate
n/a
Meas. Tech.
ChEBML_160080
IC50
4600±n/a nM
Citation
 Kakuta, H; Koiso, Y; Nagasawa, K; Hashimoto, Y Fluorescent bioprobes for visualization of puromycin-sensitive aminopeptidase in living cells. Bioorg Med Chem Lett 13:83-6 (2002) [PubMed]  Article 
Target
Name:
Puromycin-sensitive aminopeptidase
Synonyms:
Aminopeptidase | NPEPPS | PSA | PSA_HUMAN
Type:
PROTEIN
Mol. Mass.:
103262.98
Organism:
Homo sapiens (Human)
Description:
ChEMBL_160080
Residue:
919
Sequence:
MWLAAAAPSLARRLLFLGPPPPPLLLLVFSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDIITASYAPEGDEEIHATGFNYQNEDEKVTLSFPSTLQTGTGTLKIDFVGELNDKMKGFYRSKYTTPSGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPDDENLVEVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGKFALEVAAKTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQELDALDNSHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAATEDLWESLENASGKPIAAVMNTWTKQMGFPLIYVEAEQVEDDRLLRLSQKKFCAGGSYVGEDCPQWMVPITISTSEDPNQAKLKILMDKPEMNVVLKNVKPDQWVKLNLGTVGFYRTQYSSAMLESLLPGIRDLSLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNLGILSTLLSHTDFYEEIQEFVKDVFSPIGERLGWDPKPGEGHLDALLRGLVLGKLGKAGHKATLEEARRRFKDHVEGKQILSADLRSPVYLTVLKHGDGTTLDIMLKLHKQADMQEEKNRIERVLGATLLPDLIQKVLTFALSEEVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEELYNRYQGGFLISRLIKLSVEGFAVDKMAGEVKAFFESHPAPSAERTIQQCCENILLNAAWLKRDAESIHQYLLQRKASPPTV
  
Inhibitor
Name:
BDBM50121711
Synonyms:
CHEMBL169895 | DAMPAQ
Type:
Small organic molecule
Emp. Form.:
C31H32N4O4S
Mol. Mass.:
556.675
SMILES:
CCc1cc(NS(=O)(=O)c2ccc3c(cccc3c2)N(C)C)cc(CC)c1-n1c(=O)n(C)c2ccccc2c1=O |(6.43,-1.61,;6.43,-3.15,;7.78,-3.92,;9.1,-3.15,;10.44,-3.92,;11.76,-3.15,;11.76,-1.61,;13.3,-1.61,;10.23,-1.64,;11.76,-.08,;10.43,.68,;10.41,2.23,;11.74,3,;11.74,4.55,;13.07,5.35,;14.43,4.58,;14.44,3.02,;13.09,2.23,;13.11,.7,;10.41,5.31,;10.39,6.84,;9.08,4.53,;10.43,-5.47,;9.1,-6.22,;9.09,-7.76,;10.41,-8.54,;7.78,-5.46,;6.43,-6.22,;6.43,-7.76,;7.76,-8.54,;5.08,-8.53,;5.08,-10.06,;3.76,-7.76,;2.43,-8.53,;1.1,-7.76,;1.1,-6.22,;2.43,-5.45,;3.76,-6.22,;5.1,-5.43,;5.1,-3.9,)|
Structure:
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