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Target
Cathepsin B
Ligand
BDBM50121906
Substrate
n/a
Meas. Tech.
ChEBML_47599
IC50
6460±n/a nM
Citation
 Zhou, NE; Guo, D; Thomas, G; Reddy, AV; Kaleta, J; Purisima, E; Menard, R; Micetich, RG; Singh, R 3-Acylamino-azetidin-2-one as a novel class of cysteine proteases inhibitors. Bioorg Med Chem Lett 13:139-41 (2002) [PubMed]  Article 
Target
Name:
Cathepsin B
Synonyms:
CATB_RAT | Ctsb
Type:
Protein
Mol. Mass.:
37463.53
Organism:
Rattus norvegicus
Description:
P00787
Residue:
339
Sequence:
MWWSLIPLSCLLALTSAHDKPSSHPLSDDMINYINKQNTTWQAGRNFYNVDISYLKKLCGTVLGGPNLPERVGFSEDINLPESFDAREQWSNCPTIAQIRDQGSCGSCWAFGAVEAMSDRICIHTNGRVNVEVSAEDLLTCCGIQCGDGCNGGYPSGAWNFWTRKGLVSGGVYNSHIGCLPYTIPPCEHHVNGSRPPCTGEGDTPKCNKMCEAGYSTSYKEDKHYGYTSYSVSDSEKEIMAEIYKNGPVEGAFTVFSDFLTYKSGVYKHEAGDVMGGHAIRILGWGIENGVPYWLVANSWNVDWGDNGFFKILRGENHCGIESEIVAGIPRTQQYWGRF
  
Inhibitor
Name:
BDBM50121906
Synonyms:
CHEMBL31363 | [(S)-1-((2S,3S)-2-Isobutoxy-4-oxo-azetidin-3-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester
Type:
Small organic molecule
Emp. Form.:
C24H29N3O5
Mol. Mass.:
439.5042
SMILES:
CC(C)CO[C@@H]1NC(=O)[C@H]1NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1
Structure:
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