Reaction Details Report a problem with these data
Target
Mitogen-activated protein kinase 14
Ligand
BDBM50122378
Substrate
n/a
Meas. Tech.
ChEBML_124486
IC50
1.4±n/a nM
Citation
 Stelmach, JE; Liu, L; Patel, SB; Pivnichny, JV; Scapin, G; Singh, S; Hop, CE; Wang, Z; Strauss, JR; Cameron, PM; Nichols, EA; O'Keefe, SJ; O'Neill, EA; Schmatz, DM; Schwartz, CD; Thompson, CM; Zaller, DM; Doherty, JB Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase. Bioorg Med Chem Lett 13:277-80 (2002) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50122378
Synonyms:
5-(2-Chloro-phenyl)-1-(2,6-dichloro-phenyl)-7-piperazin-1-yl-3,4-dihydro-1H-quinazolin-2-one | 5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-7-(piperazin-1-yl)-3,4-dihydroquinazolin-2(1H)-one | CHEMBL96487
Type:
Small organic molecule
Emp. Form.:
C24H21Cl3N4O
Mol. Mass.:
487.809
SMILES:
Clc1ccccc1-c1cc(cc2N(C(=O)NCc12)c1c(Cl)cccc1Cl)N1CCNCC1
Structure:
Search PDB for entries with ligand similarity: