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Target
Metallo-beta-lactamase GIM-1
Ligand
BDBM50560024
Substrate
n/a
Meas. Tech.
ChEMBL_2071127 (CHEMBL4726661)
IC50
83000±n/a nM
Citation
 Muhammad, Z; Skagseth, S; Boomgaren, M; Akhter, S; Fröhlich, C; Ismael, A; Christopeit, T; Bayer, A; Leiros, HS Structural studies of triazole inhibitors with promising inhibitor effects against antibiotic resistance metallo-?-lactamases. Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
Metallo-beta-lactamase GIM-1
Synonyms:
GIM-1 | GIM-1 protein | Metallo-beta-lactamase GIM-1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27418.35
Organism:
Pseudomonas aeruginosa
Description:
n/a
Residue:
250
Sequence:
MKNVLVFLILLVALPALAQGHKPLEVIKIEDGVYLHTSFKNIEGYGLVDSNGLVVLDNNQAYIIDTPWSEEDTKLLLSWATDRGYQVMASISTHSHEDRTAGIKLLNSKSIPTYTSELTKKLLAREGKPVPTHYFKDDEFTLGNGLIELYYPGAGHTEDNIVAWLPKSKILFGGCLVRSHEWEGLGYVGDASISSWADSIKNIVSKKYPIQMVVPGHGKVGSSDILDHTIDLAESASNKLMQPTAEASAD
  
Inhibitor
Name:
BDBM50560024
Synonyms:
CHEMBL4741814
Type:
Small organic molecule
Emp. Form.:
C21H29N5O2S
Mol. Mass.:
415.552
SMILES:
Cc1ccc(cc1)S(=O)(=O)NCc1[nH]nnc1CNC12CC3CC(CC(C3)C1)C2 |TLB:22:23:20.21.26:27,THB:22:21:27:28.23.24,24:23:20:26.25.27,24:25:20:28.22.23|
Structure:
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