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Target
Melanocortin receptor 4
Ligand
BDBM50122506
Substrate
n/a
Meas. Tech.
ChEMBL_106341 (CHEMBL713796)
IC50
2146±n/a nM
Citation
 Arasasingham, PN; Fotsch, C; Ouyang, X; Norman, MH; Kelly, MG; Stark, KL; Karbon, B; Hale, C; Baumgartner, JW; Zambrano, M; Cheetham, J; Tamayo, NA Structure-activity relationship of (1-aryl-2-piperazinylethyl)piperazines: antagonists for the AGRP/melanocortin receptor binding. J Med Chem 46:9-11 (2002) [PubMed]  Article 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM50122506
Synonyms:
3-{4-[2-(4-Fluoro-phenyl)-2-(4-methyl-piperazin-1-yl)-ethyl]-piperazin-1-yl}-1-(4-methoxy-phenyl)-2-methyl-propan-1-one | CHEMBL12369
Type:
Small organic molecule
Emp. Form.:
C28H39FN4O2
Mol. Mass.:
482.6333
SMILES:
COc1ccc(cc1)C(=O)C(C)CN1CCN(CC(N2CCN(C)CC2)c2ccc(F)cc2)CC1
Structure:
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