Reaction Details Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM50122507
Substrate
n/a
Meas. Tech.
ChEMBL_106341 (CHEMBL713796)
IC50
2862±n/a nM
Citation
 Arasasingham, PN; Fotsch, C; Ouyang, X; Norman, MH; Kelly, MG; Stark, KL; Karbon, B; Hale, C; Baumgartner, JW; Zambrano, M; Cheetham, J; Tamayo, NA Structure-activity relationship of (1-aryl-2-piperazinylethyl)piperazines: antagonists for the AGRP/melanocortin receptor binding. J Med Chem 46:9-11 (2002) [PubMed]  Article 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM50122507
Synonyms:
3-{4-[2-(4-Fluoro-phenyl)-2-(4-phenyl-piperazin-1-yl)-ethyl]-piperazin-1-yl}-2-methyl-1-phenyl-propan-1-one | CHEMBL416890
Type:
Small organic molecule
Emp. Form.:
C32H39FN4O
Mol. Mass.:
514.6767
SMILES:
CC(CN1CCN(CC(N2CCN(CC2)c2ccccc2)c2ccc(F)cc2)CC1)C(=O)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: