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Target
Patatin-like phospholipase domain-containing protein 2
Ligand
BDBM50560129
Substrate
n/a
Meas. Tech.
ChEMBL_2071473 (CHEMBL4727007)
IC50
9000±n/a nM
Citation
 Mayer, N; Schweiger, M; Fuchs, E; Migglautsch, AK; Doler, C; Grabner, GF; Romauch, M; Melcher, MC; Zechner, R; Zimmermann, R; Breinbauer, R Structure-activity relationship studies for the development of inhibitors of murine adipose triglyceride lipase (ATGL). Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
Patatin-like phospholipase domain-containing protein 2
Synonyms:
Adipose triglyceride lipase | Atgl | Desnutrin | PLPL2_MOUSE | Patatin-like phospholipase domain-containing protein 2 | Pnpla2
Type:
PROTEIN
Mol. Mass.:
53655.79
Organism:
Mus musculus
Description:
ChEMBL_109612
Residue:
486
Sequence:
MFPRETKWNISFAGCGFLGVYHIGVASCLREHAPFLVANATHIYGASAGALTATALVTGACLGEAGANIIEVSKEARKRFLGPLHPSFNLVKTIRGCLLKTLPADCHERANGRLGISLTRVSDGENVIISHFSSKDELIQANVCSTFIPVYCGLIPPTLQGVRYVDGGISDNLPLYELKNTITVSPFSGESDICPQDSSTNIHELRVTNTSIQFNLRNLYRLSKALFPPEPMVLREMCKQGYRDGLRFLRRNGLLNQPNPLLALPPVVPQEEDAEEAAVVEERAGEEDQLQPYRKDRILEHLPARLNEALLEACVEPKDLMTTLSNMLPVRLATAMMVPYTLPLESAVSFTIRLLEWLPDVPEDIRWMKEQTGSICQYLVMRAKRKLGDHLPSRLSEQVELRRAQSLPSVPLSCATYSEALPNWVRNNLSLGDALAKWEECQRQLLLGLFCTNVAFPPDALRMRAPASPTAADPATPQDPPGLPPC
  
Inhibitor
Name:
BDBM50560129
Synonyms:
CHEMBL4744133
Type:
Small organic molecule
Emp. Form.:
C17H20N2O2
Mol. Mass.:
284.3529
SMILES:
CCOc1ccc(cc1)-c1cccc(NC(=O)N(C)C)c1
Structure:
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