Reaction Details Report a problem with these data
Target
Nuclear receptor subfamily 1 group D member 1
Ligand
BDBM50434030
Substrate
n/a
Meas. Tech.
ChEMBL_2072143 (CHEMBL4727677)
EC50
160±n/a nM
Citation
 Uriz-Huarte, A; Date, A; Ang, H; Ali, S; Brady, HJM; Fuchter, MJ The transcriptional repressor REV-ERB as a novel target for disease. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Nuclear receptor subfamily 1 group D member 1
Synonyms:
EAR-1 | EAR1 | HREV | NR1D1 | NR1D1_HUMAN | Rev-erbA-alpha | THRAL | V-erbA-related protein 1
Type:
PROTEIN
Mol. Mass.:
66822.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_958222
Residue:
614
Sequence:
MTTLDSNNNTGGVITYIGSSGSSPSRTSPESLYSDNSNGSFQSLTQGCPTYFPPSPTGSLTQDPARSFGSIPPSLSDDGSPSSSSSSSSSSSSFYNGSPPGSLQVAMEDSSRVSPSKSTSNITKLNGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKRCLKNENCSIVRINRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLAEMQSAMNLANNQLSSQCPLETSPTQHPTPGPMGPSPPPAPVPSPLVGFSQFPQQLTPPRSPSPEPTVEDVISQVARAHREIFTYAHDKLGSSPGNFNANHASGSPPATTPHRWENQGCPPAPNDNNTLAAQRHNEALNGLRQAPSSYPPTWPPGPAHHSCHQSNSNGHRLCPTHVYAAPEGKAPANSPRQGNSKNVLLACPMNMYPHGRSGRTVQEIWEDFSMSFTPAVREVVEFAKHIPGFRDLSQHDQVTLLKAGTFEVLMVRFASLFNVKDQTVMFLSRTTYSLQELGAMGMGDLLSAMFDFSEKLNSLALTEEELGLFTAVVLVSADRSGMENSASVEQLQETLLRALRALVLKNRPLETSRFTKLLLKLPDLRTLNNMHSEKLLSFRVDAQ
  
Inhibitor
Name:
BDBM50434030
Synonyms:
CHEMBL2381202
Type:
Small organic molecule
Emp. Form.:
C18H16FN3O2S
Mol. Mass.:
357.402
SMILES:
[O-][N+](=O)c1ccc(CN(Cc2ccc(F)cc2)Cc2cccnc2)s1
Structure:
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