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Target
Bone morphogenetic protein receptor type-1A
Ligand
BDBM50560468
Substrate
n/a
Meas. Tech.
ChEMBL_2072221 (CHEMBL4727755)
IC50
<5.0±n/a nM
Citation
 Engers, DW; Bollinger, SR; Felts, AS; Vadukoot, AK; Williams, CH; Blobaum, AL; Lindsley, CW; Hong, CC; Hopkins, CR Discovery, synthesis and characterization of a series of 7-aryl-imidazo[1,2-a]pyridine-3-ylquinolines as activin-like kinase (ALK) inhibitors. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Bone morphogenetic protein receptor type-1A
Synonyms:
ACVRLK3 | ALK3 | Activin receptor-like kinase 3 (ALK-3) | BMPR1A | BMR1A_HUMAN
Type:
Enzyme
Mol. Mass.:
60204.46
Organism:
Homo sapiens (Human)
Description:
P36894
Residue:
532
Sequence:
MPQLYIYIRLLGAYLFIISRVQGQNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYCKSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI
  
Inhibitor
Name:
BDBM50560468
Synonyms:
CHEMBL4786529
Type:
Small organic molecule
Emp. Form.:
C27H23F2N5
Mol. Mass.:
455.5018
SMILES:
Cc1cc(-c2cnc3cc(ccn23)-c2ccc(cc2)N2CCNCC2)c2cc(F)cc(F)c2n1
Structure:
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