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Target
Cyclin-dependent kinase 9
Ligand
BDBM50560719
Substrate
n/a
Meas. Tech.
ChEMBL_2072948 (CHEMBL4728482)
IC50
5.9±n/a nM
Citation
 Lv, K; Chen, W; Chen, D; Mou, J; Zhang, H; Fan, T; Li, Y; Cao, D; Wang, X; Chen, L; Shen, J; Pei, D; Xiong, B Rational Design and Evaluation of 6-(Pyrimidin-2-ylamino)-3,4-dihydroquinoxalin-2(1 J Med Chem 63:9787-9802 (2020) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 9
Synonyms:
C-2K | CDC2L4 | CDK9 | CDK9_HUMAN | Cell division cycle 2-like protein kinase 4 | Cell division protein kinase 9 | Cyclin-Dependent Kinase 9 (CDK9) | Cyclin-dependent kinase 9 (CDK9) | Serine/threonine-protein kinase PITALRE | TAK | Tat-associated kinase complex catalytic subunit
Type:
Enzyme Subunit
Mol. Mass.:
42789.13
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
372
Sequence:
MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF
  
Inhibitor
Name:
BDBM50560719
Synonyms:
CHEMBL4755696
Type:
Small organic molecule
Emp. Form.:
C23H26N6O
Mol. Mass.:
402.4921
SMILES:
CC(C)N1[C@H](C)C(=O)N(C)c2ccc(Nc3nccc(n3)-c3cccc(N)c3)cc12 |r|
Structure:
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