Reaction Details Report a problem with these data
Target
Arginase-1
Ligand
BDBM50230418
Substrate
n/a
Meas. Tech.
ChEMBL_2074192 (CHEMBL4729726)
IC50
20000±n/a nM
Citation
 Borek, B; Gajda, T; Golebiowski, A; Blaszczyk, R Boronic acid-based arginase inhibitors in cancer immunotherapy. Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
Arginase-1
Synonyms:
ARGI1_RAT | Arg1 | Liver-type arginase | Type I arginase
Type:
PROTEIN
Mol. Mass.:
34976.26
Organism:
Rattus norvegicus
Description:
ChEMBL_108287
Residue:
323
Sequence:
MSSKPKPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYLKPPK
  
Inhibitor
Name:
BDBM50230418
Synonyms:
CHEMBL260629 | N(gamma)-hydroxy-L-arginine | N-OMEGA-HYDROXY-L-ARGININE | Nomega-hydroxy-L-arginine
Type:
Small organic molecule
Emp. Form.:
C6H14N4O3
Mol. Mass.:
190.2004
SMILES:
NC(NO)=NCCC[C@H]([NH3+])C([O-])=O |r,w:4.4|
Structure:
Search PDB for entries with ligand similarity: