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Target
Fructose-1,6-bisphosphatase 1
Ligand
BDBM50561062
Substrate
n/a
Meas. Tech.
ChEMBL_2074227 (CHEMBL4729761)
IC50
30000±n/a nM
Citation
 Han, X; Huang, Y; Wei, L; Chen, H; Guo, Y; Tang, Z; Hu, W; Xia, Q; Wang, Q; Yan, J; Ren, Y Biological evaluation and SAR analysis of novel covalent inhibitors against fructose-1,6-bisphosphatase. Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
Fructose-1,6-bisphosphatase 1
Synonyms:
D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 | F16P1_HUMAN | FBP | FBP1 | FBPase 1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1 | Fructose-1,6-bisphosphatase 1 (FBPase)
Type:
Protein
Mol. Mass.:
36843.58
Organism:
Homo sapiens (Human)
Description:
Liver FBPase (P09467)
Residue:
338
Sequence:
MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
  
Inhibitor
Name:
BDBM50561062
Synonyms:
CHEMBL4778310
Type:
Small organic molecule
Emp. Form.:
C9H9NO2S
Mol. Mass.:
195.238
SMILES:
CSc1ccc(\C=C\[N+]([O-])=O)cc1
Structure:
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