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Target
Succinate receptor 1
Ligand
BDBM50561205
Substrate
n/a
Meas. Tech.
ChEMBL_2074424 (CHEMBL4729958)
IC50
88±n/a nM
Citation
 Velcicky, J; Wilcken, R; Cotesta, S; Janser, P; Schlapbach, A; Wagner, T; Piechon, P; Villard, F; Bouhelal, R; Piller, F; Harlfinger, S; Stringer, R; Fehlmann, D; Kaupmann, K; Littlewood-Evans, A; Haffke, M; Gommermann, N Discovery and Optimization of Novel SUCNR1 Inhibitors: Design of Zwitterionic Derivatives with a Salt Bridge for the Improvement of Oral Exposure. J Med Chem 63:9856-9875 (2020) [PubMed]  Article 
Target
Name:
Succinate receptor 1
Synonyms:
G-protein coupled receptor 91 | GPR91 | P2Y purinoceptor 1-like | SUCNR1 | SUCR1_HUMAN
Type:
PROTEIN
Mol. Mass.:
38709.48
Organism:
Homo sapiens (Human)
Description:
ChEMBL_852820
Residue:
334
Sequence:
MLGIMAWNATCKNWLAAEAALEKYYLSIFYGIEFVVGVLGNTIVVYGYIFSLKNWNSSNIYLFNLSVSDLAFLCTLPMLIRSYANGNWIYGDVLCISNRYVLHANLYTSILFLTFISIDRYLIIKYPFREHLLQKKEFAILISLAIWVLVTLELLPILPLINPVITDNGTTCNDFASSGDPNYNLIYSMCLTLLGFLIPLFVMCFFYYKIALFLKQRNRQVATALPLEKPLNLVIMAVVIFSVLFTPYHVMRNVRIASRLGSWKQYQCTQVVINSFYIVTRPLAFLNSVINPVFYFLLGDHFRDMLMNQLRHNFKSLTSFSRWAHELLLSFREK
  
Inhibitor
Name:
BDBM50561205
Synonyms:
CHEMBL4751488
Type:
Small organic molecule
Emp. Form.:
C26H22ClF3N2O4
Mol. Mass.:
518.912
SMILES:
OC(=O)Cc1cc(F)ccc1NC(=O)c1cccc(c1F)-c1cc(O[C@@H]2CCCNC2)c(Cl)cc1F |r|
Structure:
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