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Target
Ubiquitin-like modifier-activating enzyme ATG7
Ligand
BDBM476001
Substrate
n/a
Meas. Tech.
ChEMBL_2074574 (CHEMBL4730108)
IC50
17±n/a nM
Citation
 Huang, SC; Adhikari, S; Brownell, JE; Calderwood, EF; Chouitar, J; D'Amore, NR; England, DB; Foley, K; Harrison, SJ; LeRoy, PJ; Lok, D; Lublinsky, A; Ma, LT; Menon, S; Yang, Y; Zhang, J; Gould, AE Discovery and optimization of pyrazolopyrimidine sulfamates as ATG7 inhibitors. Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
Ubiquitin-like modifier-activating enzyme ATG7
Synonyms:
APG7-like | APG7L | ATG12-activating enzyme E1 ATG7 | ATG7 | ATG7_HUMAN | Autophagy-related protein 7 | Ubiquitin-activating enzyme E1-like protein | hAGP7
Type:
PROTEIN
Mol. Mass.:
77955.74
Organism:
Homo sapiens (Human)
Description:
ChEMBL_939703
Residue:
703
Sequence:
MAAATGDPGLSKLQFAPFSSALDVGFWHELTQKKLNEYRLDEAPKDIKGYYYNGDSAGLPARLTLEFSAFDMSAPTPARCCPAIGTLYNTNTLESFKTADKKLLLEQAANEIWESIKSGTALENPVLLNKFLLLTFADLKKYHFYYWFCYPALCLPESLPLIQGPVGLDQRFSLKQIEALECAYDNLCQTEGVTALPYFLIKYDENMVLVSLLKHYSDFFQGQRTKITIGVYDPCNLAQYPGWPLRNFLVLAAHRWSSSFQSVEVVCFRDRTMQGARDVAHSIIFEVKLPEMAFSPDCPKAVGWEKNQKGGMGPRMVNLSECMDPKRLAESSVDLNLKLMCWRLVPTLDLDKVVSVKCLLLGAGTLGCNVARTLMGWGVRHITFVDNAKISYSNPVRQPLYEFEDCLGGGKPKALAAADRLQKIFPGVNARGFNMSIPMPGHPVNFSSVTLEQARRDVEQLEQLIESHDVVFLLMDTRESRWLPAVIAASKRKLVINAALGFDTFVVMRHGLKKPKQQGAGDLCPNHPVASADLLGSSLFANIPGYKLGCYFCNDVVAPGDSTRDRTLDQQCTVSRPGLAVIAGALAVELMVSVLQHPEGGYAIASSSDDRMNEPPTSLGLVPHQIRGFLSRFDNVLPVSLAFDKCTACSSKVLDQYEREGFNFLAKVFNSSHSFLEDLTGLTLLHQETQAAEIWDMSDDETI
  
Inhibitor
Name:
BDBM476001
Synonyms:
US10865208, Compound I-58 | {(2R,3S,4R,5R)-5-[4-amino-3-(isopropylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin- 1-yl]-3,4-dihydroxytetrahydrofuran-2-yl}methyl sulfamate
Type:
Small organic molecule
Emp. Form.:
C13H20N6O6S2
Mol. Mass.:
420.464
SMILES:
CC(C)Sc1nn([C@@H]2O[C@H](COS(N)(=O)=O)[C@@H](O)[C@H]2O)c2ncnc(N)c12 |r|
Structure:
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