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Target
Dihydropyrimidine dehydrogenase [NADP(+)]
Ligand
BDBM50124200
Substrate
n/a
Meas. Tech.
ChEBML_53186
IC50
43±n/a nM
Citation
 Hattori, K; Kohchi, Y; Oikawa, N; Suda, H; Ura, M; Ishikawa, T; Miwa, M; Endoh, M; Eda, H; Tanimura, H; Kawashima, A; Horii, I; Ishitsuka, H; Shimma, N Design and synthesis of the tumor-activated prodrug of dihydropyrimidine dehydrogenase (DPD) inhibitor, RO0094889 for combination therapy with capecitabine. Bioorg Med Chem Lett 13:867-72 (2003) [PubMed]  Article 
Target
Name:
Dihydropyrimidine dehydrogenase [NADP(+)]
Synonyms:
DHPDHase | DPD | DPYD | DPYD_HUMAN | Dihydropyrimidine dehydrogenase | Dihydropyrimidine dehydrogenase [NADP+] | Dihydrothymine dehydrogenase | Dihydrouracil dehydrogenase
Type:
PROTEIN
Mol. Mass.:
111404.27
Organism:
Homo sapiens (Human)
Description:
ChEMBL_53186
Residue:
1025
Sequence:
MAPVLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKHWKRNPDKNCFNCEKLENNFDDIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIANKNYYGAAKMIFSDNPLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFATEVFKAMSIPQIRNPSLPPPEKMSEAYSAKIALFGAGPASISCASFLARLGYSDITIFEKQEYVGGLSTSEIPQFRLPYDVVNFEIELMKDLGVKIICGKSLSVNEMTLSTLKEKGYKAAFIGIGLPEPNKDAIFQGLTQDQGFYTSKDFLPLVAKGSKAGMCACHSPLPSIRGVVIVLGAGDTAFDCATSALRCGARRVFIVFRKGFVNIRAVPEEMELAKEEKCEFLPFLSPRKVIVKGGRIVAMQFVRTEQDETGKWNEDEDQMVHLKADVVISAFGSVLSDPKVKEALSPIKFNRWGLPEVDPETMQTSEAWVFAGGDVVGLANTTVESVNDGKQASWYIHKYVQSQYGASVSAKPELPLFYTPIDLVDISVEMAGLKFINPFGLASATPATSTSMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRIIRGTTSGPMYGPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNKNDWTELAKKSEDSGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVQIPFFAKLTPNVTDIVSIARAAKEGGANGVTATNTVSGLMGLKSDGTPWPAVGIAKRTTYGGVSGTAIRPIALRAVTSIARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYLKSIEELQDWDGQSPATVSHQKGKPVPRIAELMDKKLPSFGPYLEQRKKIIAENKIRLKEQNVAFSPLKRNCFIPKRPIPTIKDVIGKALQYLGTFGELSNVEQVVAMIDEEMCINCGKCYMTCNDSGYQAIQFDPETHLPTITDTCTGCTLCLSVCPIVDCIKMVSRTTPYEPKRGVPLSVNPVC
  
Inhibitor
Name:
BDBM50124200
Synonyms:
5-((E)-Styryl)-1H-pyrimidine-2,4-dione | CHEMBL352944
Type:
Small organic molecule
Emp. Form.:
C12H10N2O2
Mol. Mass.:
214.22
SMILES:
O=c1[nH]cc(C=Cc2ccccc2)c(=O)[nH]1 |w:6.6|
Structure:
Search PDB for entries with ligand similarity: