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Target
Excitatory amino acid transporter 4
Ligand
BDBM50561803
Substrate
n/a
Meas. Tech.
ChEMBL_2075999 (CHEMBL4731533)
IC50
1585±n/a nM
Citation
 Liu, N; Jensen, AA; Bunch, L ?-Indolyloxy Functionalized Aspartate Analogs as Inhibitors of the Excitatory Amino Acid Transporters (EAATs). ACS Med Chem Lett 11:2212-2220 (2020) [PubMed]  Article 
Target
Name:
Excitatory amino acid transporter 4
Synonyms:
EAA4_RAT | Eaat4 | Excitatory amino acid transporter 4 | High-affinity neuronal glutamate transporter | Slc1a6 | Sodium-dependent glutamate/aspartate transporter | Solute carrier family 1 member 6
Type:
PROTEIN
Mol. Mass.:
60724.56
Organism:
Rattus norvegicus
Description:
ChEMBL_100180
Residue:
561
Sequence:
MSSHGNSLFLRESGAGGGCLQGLQDSLQQRALRTRLRLQTMTREHVRRFLRRNAFILLTVSAVIIGVSLAFALRPYQLTYRQIKYFSFPGELLMRMLQMLVLPLIVSSRVTGMASLDNKATGRMGMRAAVYYMVTTVIAVFIGILMVTIIHPGKGSKEGLHREGRIETVPTADAFMDLVRNMFPPNLVEACFKQFKTQYSTRVVTRTIVRTDNGSELGASISPPSSAENETSILENVTRALGTLQEVISFEETVPVPGSANGINALGLVVFSVAFGLVIGGMKHKGRVLRDFFDSLNEAIMRLVGIIIWYAPVGILFLIAGKILEMEDMAVLGGQLGMYTLTVIVGLFLHAGGVLPLIYFLVTHRNPFPFIGGILQALITAMGTSSSSATLPITFRCLEEGLGVDRRITRFVLPVGATVNMDGTALYEALAAIFIAQVNNYELNLGQITTISITATAASVGAAGIPQAGLVTMVIVLTSVGLPTEDITLIIAVDWFLDRLRTMTNVLGDSIGAAVIEHLSQRELELQEAELTLPSLGKPYKSLMAQAKGASRGRGGNESVM
  
Inhibitor
Name:
BDBM50561803
Synonyms:
CHEMBL4790691
Type:
Small organic molecule
Emp. Form.:
C29H24F6N2O9S
Mol. Mass.:
690.564
SMILES:
OC(=O)C(F)(F)F.Cc1ccc(cc1)S(=O)(=O)n1cc(-c2ccc(cc2)C(F)(F)F)c2ccc(CO[C@@H]([C@H](N)C(O)=O)C(O)=O)cc12 |r|
Structure:
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