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Target
Target of rapamycin complex subunit LST8
Ligand
BDBM50562006
Substrate
n/a
Meas. Tech.
ChEMBL_2076648 (CHEMBL4732439)
IC50
67±n/a nM
Citation
 Borsari, C; Keles, E; Treyer, A; De Pascale, M; Hebeisen, P; Hamburger, M; Wymann, MP Second-generation tricyclic pyrimido-pyrrolo-oxazine mTOR inhibitor with predicted blood-brain barrier permeability. RSC Med Chem 12:579-583 (2021) [PubMed]  Article 
Target
Name:
Target of rapamycin complex subunit LST8
Synonyms:
G protein beta subunit-like | GBL | Gable | LST8 | LST8_HUMAN | MLST8 | Mammalian lethal with SEC13 protein 8 | Protein GbetaL | TORC subunit LST8 | Target of rapamycin complex subunit LST8
Type:
PROTEIN
Mol. Mass.:
35871.25
Organism:
Homo sapiens
Description:
ChEMBL_118692
Residue:
326
Sequence:
MNTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDSVLG
  
Inhibitor
Name:
BDBM50562006
Synonyms:
CHEMBL4741382
Type:
Small organic molecule
Emp. Form.:
C20H24F2N6O2
Mol. Mass.:
418.4404
SMILES:
[H][C@]12Cc3c(nc(nc3N3CCOC[C@H]3C)-c3cnc(N)cc3C(F)F)N1CCOC2 |r|
Structure:
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