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Target
Proteinase-activated receptor 4
Ligand
BDBM176033
Substrate
n/a
Meas. Tech.
ChEMBL_2077649 (CHEMBL4733440)
IC50
0.450000±n/a nM
Citation
 Liu, S; Li, S; Yuan, D; Wang, E; Xie, R; Zhang, W; Kong, Y; Zhu, X Protease activated receptor 4 (PAR4) antagonists: Research progress on small molecules in the field of antiplatelet agents. Eur J Med Chem 209:0 (2021) [PubMed]  Article 
Target
Name:
Proteinase-activated receptor 4
Synonyms:
Coagulation factor II receptor-like 3 | F2RL3 | PAR-4 | PAR4 | PAR4_HUMAN | Proteinase-activated receptor 4 | Proteinase-activated receptor 4 (PAR4) | Thrombin receptor-like 3
Type:
Protein
Mol. Mass.:
41145.16
Organism:
Homo sapiens (Human)
Description:
Q96RI0
Residue:
385
Sequence:
MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
  
Inhibitor
Name:
BDBM176033
Synonyms:
US10047103, 66 | US9688695, 66
Type:
Small organic molecule
Emp. Form.:
C28H25N5O5S2
Mol. Mass.:
575.659
SMILES:
COc1nn2cc(nc2s1)-c1cc2c(OCc3nc(sc3C)-c3ccc(cc3)C(=O)N(C)C)cc(OC)cc2o1
Structure:
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