Reaction Details Report a problem with these data
Target
Forkhead box protein M1
Ligand
BDBM50562257
Substrate
n/a
Meas. Tech.
ChEMBL_2077765 (CHEMBL4733556)
IC50
50540±n/a nM
Citation
 Tabatabaei Dakhili, SA; Pérez, DJ; Gopal, K; Haque, M; Ussher, JR; Kashfi, K; Velázquez-Martínez, CA SP1-independent inhibition of FOXM1 by modified thiazolidinediones. Eur J Med Chem 209:0 (2021) [PubMed]  Article 
Target
Name:
Forkhead box protein M1
Synonyms:
FKHL16 | FOXM1 | FOXM1_HUMAN | Forkhead box protein M1 | Forkhead-related protein FKHL16 | HFH-11 | HFH11 | HNF-3/fork-head homolog 11 | Hepatocyte nuclear factor 3 forkhead homolog 11 | M-phase phosphoprotein 2 | MPM-2 reactive phosphoprotein 2 | MPP2 | Transcription factor Trident | WIN | Winged-helix factor from INS-1 cells
Type:
PROTEIN
Mol. Mass.:
84290.86
Organism:
Homo sapiens
Description:
ChEMBL_120188
Residue:
763
Sequence:
MKTSPRRPLILKRRRLPLPVQNAPSETSEEEPKRSPAQQESNQAEASKEVAESNSCKFPAGIKIINHPTMPNTQVVAIPNNANIHSIITALTAKGKESGSSGPNKFILISCGGAPTQPPGLRPQTQTSYDAKRTEVTLETLGPKPAARDVNLPRPPGALCEQKRETCADGEAAGCTINNSLSNIQWLRKMSSDGLGSRSIKQEMEEKENCHLEQRQVKVEEPSRPSASWQNSVSERPPYSYMAMIQFAINSTERKRMTLKDIYTWIEDHFPYFKHIAKPGWKNSIRHNLSLHDMFVRETSANGKVSFWTIHPSANRYLTLDQVFKPLDPGSPQLPEHLESQQKRPNPELRRNMTIKTELPLGARRKMKPLLPRVSSYLVPIQFPVNQSLVLQPSVKVPLPLAASLMSSELARHSKRVRIAPKVLLAEEGIAPLSSAGPGKEEKLLFGEGFSPLLPVQTIKEEEIQPGEEMPHLARPIKVESPPLEEWPSPAPSFKEESSHSWEDSSQSPTPRPKKSYSGLRSPTRCVSEMLVIQHRERRERSRSRRKQHLLPPCVDEPELLFSEGPSTSRWAAELPFPADSSDPASQLSYSQEVGGPFKTPIKETLPISSTPSKSVLPRTPESWRLTPPAKVGGLDFSPVQTSQGASDPLPDPLGLMDLSTTPLQSAPPLESPQRLLSSEPLDLISVPFGNSSPSDIDVPKPGSPEPQVSGLAANRSLTEGLVLDTMNDSLSKILLDISFPGLDEDPLGPDNINWSQFIPELQ
  
Inhibitor
Name:
BDBM50562257
Synonyms:
CHEMBL4740210
Type:
Small organic molecule
Emp. Form.:
C19H14F3NO4S
Mol. Mass.:
409.379
SMILES:
COc1cc(\C=C2/SC(=O)NC2=O)ccc1COc1ccc(cc1)C(F)(F)F
Structure:
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