Reaction Details Report a problem with these data
Target
Melatonin receptor type 1B
Ligand
BDBM50125753
Substrate
n/a
Meas. Tech.
ChEMBL_105261 (CHEMBL710751)
Ki
2.33±n/a nM
Citation
 Descamps-François, C; Yous, S; Chavatte, P; Audinot, V; Bonnaud, A; Boutin, JA; Delagrange, P; Bennejean, C; Renard, P; Lesieur, D Design and synthesis of naphthalenic dimers as selective MT1 melatoninergic ligands. J Med Chem 46:1127-9 (2003) [PubMed]  Article 
Target
Name:
Melatonin receptor type 1B
Synonyms:
MTNR1B | MTR1B_HUMAN | Mel-1B-R | Mel1b melatonin receptor | Melatonin 1B | Melatonin receptor | Melatonin receptor type 1B | Melatonin receptor type 2 (MT2)
Type:
Enzyme
Mol. Mass.:
40203.54
Organism:
Homo sapiens (Human)
Description:
P49286
Residue:
362
Sequence:
MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLLVILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVMGLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGSLEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRLCLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFNSCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQADAL
  
Inhibitor
Name:
BDBM50125753
Synonyms:
CHEMBL13985 | N-[2-(7-{6-[8-(2-Acetylamino-ethyl)-naphthalen-2-yloxy]-hexyloxy}-naphthalen-1-yl)-ethyl]-acetamide
Type:
Small organic molecule
Emp. Form.:
C34H40N2O4
Mol. Mass.:
540.6924
SMILES:
CC(=O)NCCc1cccc2ccc(OCCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12
Structure:
Search PDB for entries with ligand similarity: