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Target
NEDD8-activating enzyme E1 regulatory subunit
Ligand
BDBM50562352
Substrate
n/a
Meas. Tech.
ChEMBL_2078172 (CHEMBL4733963)
IC50
9940±n/a nM
Citation
 Chen, X; Yang, X; Mao, F; Wei, J; Xu, Y; Li, B; Zhu, J; Ni, S; Jia, L; Li, J Development of novel benzimidazole-derived neddylation inhibitors for suppressing tumor growth invitro and invivo. Eur J Med Chem 210:0 (2021) [PubMed]  Article 
Target
Name:
NEDD8-activating enzyme E1 regulatory subunit
Synonyms:
APP-BP1 | APPBP1 | Amyloid beta precursor protein-binding protein 1, 59 kDa | Amyloid protein-binding protein 1 | NAE1 | Proto-oncogene protein 1 | ULA1_HUMAN
Type:
PROTEIN
Mol. Mass.:
60233.54
Organism:
Homo sapiens (Human)
Description:
ChEMBL_939705
Residue:
534
Sequence:
MAQLGKLLKEQKYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDVSGSFVEESPENLLDNDPSFFCRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNALEDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGRIPKTYKEKEDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINITKQTPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADSGKYIKLQNVYREKAKKDAAAVGNHVAKLLQSIGQAPESISEKELKLLCSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMDNPDNEIVLYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDDYVHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGMSQTSATFQL
  
Inhibitor
Name:
BDBM50562352
Synonyms:
CHEMBL4744561
Type:
Small organic molecule
Emp. Form.:
C34H30N8O2
Mol. Mass.:
582.6544
SMILES:
CCOc1nc2cccc(C(=O)NCCc3c[nH]c4ccccc34)c2n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Structure:
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