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Target
Programmed cell death 1 ligand 1
Ligand
BDBM50562589
Substrate
n/a
Meas. Tech.
ChEMBL_2079476 (CHEMBL4735267)
Kd
49500±n/a nM
Citation
 Yang, X; Cheng, B; Xiao, Y; Xue, M; Liu, T; Cao, H; Chen, J Discovery of novel CA-4 analogs as dual inhibitors of tubulin polymerization and PD-1/PD-L1 interaction for cancer treatment. Eur J Med Chem 213:0 (2021) [PubMed]  Article 
Target
Name:
Programmed cell death 1 ligand 1
Synonyms:
B7 homolog 1 | B7-H1 | B7H1 | B7H1 | CD274 | CD_antigen=CD274 | PD-L1 | PD1L1_HUMAN | PDCD1 ligand 1 | PDCD1L1 | PDCD1LG1 | PDL1 | Programmed cell death 1 ligand 1 | Programmed death ligand 1
Type:
PROTEIN
Mol. Mass.:
33278.49
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109807
Residue:
290
Sequence:
MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET
  
Inhibitor
Name:
BDBM50562589
Synonyms:
CHEMBL4759576
Type:
Small organic molecule
Emp. Form.:
C26H26O6
Mol. Mass.:
434.481
SMILES:
COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1OCc1ccc(C=O)cc1
Structure:
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