Reaction Details Report a problem with these data
Target
B2 bradykinin receptor
Ligand
BDBM50126241
Substrate
n/a
Meas. Tech.
ChEBML_40424
Ki
92±n/a nM
Citation
 Youngman, MA; Carson, JR; Lee, JS; Dax, SL; Zhang, SP; Colburn, RW; Stone, DJ; Codd, EE; Jetter, MC Synthesis and structure--activity relationships of aroylpyrrole alkylamide bradykinin (B2) antagonists. Bioorg Med Chem Lett 13:1341-4 (2003) [PubMed]  Article 
Target
Name:
B2 bradykinin receptor
Synonyms:
B2 BRADYKININ | B2 bradykinin receptor | B2R | BDKRB2 | BK-2 receptor | BKR2 | BKRB2_HUMAN | Bradykinin B2 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44467.17
Organism:
Homo sapiens (Human)
Description:
B2 BRADYKININ BDKRB2 HUMAN::P30411
Residue:
391
Sequence:
MFSPWKISMFLSVREDSVPTTASFSADMLNVTLQGPTLNGTFAQSKCPQVEWLGWLNTIQPPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNNFDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWGCTLLLSSPMLVFRTMKEYSDEGHNVTACVISYPSLIWEVFTNMLLNVVGFLLPLSVITFCTMQIMQVLRNNEMQKFKEIQTERRATVLVLVVLLLFIICWLPFQISTFLDTLHRLGILSSCQDERIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRKKSWEVYQGVCQKGGCRSEPIQMENSMGTLRTSISVERQIHKLQDWAGSRQ
  
Inhibitor
Name:
BDBM50126241
Synonyms:
CHEMBL27702 | N-[2,4-Dichloro-3-(2-methyl-quinolin-8-yloxymethyl)-phenyl]-2-[5-(4-methoxy-benzoyl)-1-methyl-1H-pyrrol-2-yl]-N-methyl-acetamide
Type:
Small organic molecule
Emp. Form.:
C33H29Cl2N3O4
Mol. Mass.:
602.507
SMILES:
COc1ccc(cc1)C(=O)c1ccc(CC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)n1C
Structure:
Search PDB for entries with ligand similarity: