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Target
B2 bradykinin receptor
Ligand
BDBM50126257
Substrate
n/a
Meas. Tech.
ChEBML_40424
Ki
476.0±n/a nM
Citation
 Youngman, MA; Carson, JR; Lee, JS; Dax, SL; Zhang, SP; Colburn, RW; Stone, DJ; Codd, EE; Jetter, MC Synthesis and structure--activity relationships of aroylpyrrole alkylamide bradykinin (B2) antagonists. Bioorg Med Chem Lett 13:1341-4 (2003) [PubMed]  Article 
Target
Name:
B2 bradykinin receptor
Synonyms:
B2 BRADYKININ | B2 bradykinin receptor | B2R | BDKRB2 | BK-2 receptor | BKR2 | BKRB2_HUMAN | Bradykinin B2 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44467.17
Organism:
Homo sapiens (Human)
Description:
B2 BRADYKININ BDKRB2 HUMAN::P30411
Residue:
391
Sequence:
MFSPWKISMFLSVREDSVPTTASFSADMLNVTLQGPTLNGTFAQSKCPQVEWLGWLNTIQPPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNNFDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWGCTLLLSSPMLVFRTMKEYSDEGHNVTACVISYPSLIWEVFTNMLLNVVGFLLPLSVITFCTMQIMQVLRNNEMQKFKEIQTERRATVLVLVVLLLFIICWLPFQISTFLDTLHRLGILSSCQDERIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRKKSWEVYQGVCQKGGCRSEPIQMENSMGTLRTSISVERQIHKLQDWAGSRQ
  
Inhibitor
Name:
BDBM50126257
Synonyms:
CHEMBL27701 | N-[2,4-Dichloro-3-(2-methyl-quinolin-8-yloxymethyl)-phenyl]-N-methyl-2-[1-methyl-5-(4-trifluoromethyl-benzoyl)-1H-pyrrol-2-yl]-acetamide
Type:
Small organic molecule
Emp. Form.:
C33H26Cl2F3N3O3
Mol. Mass.:
640.479
SMILES:
CN(C(=O)Cc1ccc(C(=O)c2ccc(cc2)C(F)(F)F)n1C)c1ccc(Cl)c(COc2cccc3ccc(C)nc23)c1Cl
Structure:
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