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Target
Serine protease 1
Ligand
BDBM50126495
Substrate
n/a
Meas. Tech.
ChEBML_212866
Ki
630±n/a nM
Citation
 Sanderson, PE; Cutrona, KJ; Savage, KL; Naylor-Olsen, AM; Bickel, DJ; Bohn, DL; Clayton, FC; Krueger, JA; Lewis, SD; Lucas, BJ; Lyle, EA; Wallace, AA; Welsh, DC; Yan, Y 3-amino-4-sulfonylpyridinone acetamide and related pyridothiadiazine thrombin inhibitors. Bioorg Med Chem Lett 13:1441-4 (2003) [PubMed]  Article 
Target
Name:
Serine protease 1
Synonyms:
Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRY1_HUMAN | TRYP1 | Thrombin & trypsin | Trypsin | Trypsin I | Trypsin-1
Type:
Enzyme
Mol. Mass.:
26557.80
Organism:
Homo sapiens (Human)
Description:
P07477
Residue:
247
Sequence:
MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIAANS
  
Inhibitor
Name:
BDBM50126495
Synonyms:
2-(3-Amino-4-cyclopentylmethanesulfonyl-6-methyl-2-oxo-2H-pyridin-1-yl)-N-(6-amino-2-methyl-pyridin-3-ylmethyl)-acetamide | CHEMBL33480
Type:
Small organic molecule
Emp. Form.:
C21H29N5O4S
Mol. Mass.:
447.551
SMILES:
Cc1cc(c(N)c(=O)n1CC(=O)NCc1ccc(N)nc1C)S(=O)(=O)CC1CCCC1
Structure:
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