Reaction Details Report a problem with these data
Target
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Ligand
BDBM50126635
Substrate
n/a
Meas. Tech.
ChEBML_197827
Ki
>67000±n/a nM
Citation
 Tomczuk, B; Lu, T; Soll, RM; Fedde, C; Wang, A; Murphy, L; Crysler, C; Dasgupta, M; Eisennagel, S; Spurlino, J; Bone, R Oxyguanidines: application to non-peptidic phenyl-based thrombin inhibitors. Bioorg Med Chem Lett 13:1495-8 (2003) [PubMed]  Article 
Target
Name:
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Synonyms:
PP-1A | PP1A_HUMAN | PPP1A | PPP1CA | Serine/threonine protein phosphatase PP1-alpha catalytic subunit | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit | protein phosphatase 1, catalytic subunit, alpha isoform 3
Type:
PROTEIN
Mol. Mass.:
37510.66
Organism:
Homo sapiens (Human)
Description:
ChEMBL_197827
Residue:
330
Sequence:
MSDSEKLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPADKNKGKYGQFSGLNPGGRPITPPRNSAKAKK
  
Inhibitor
Name:
BDBM50126635
Synonyms:
3-[3-({[(Z)-amino(imino)methyl]amino}oxy)ethoxy]-5-methylphenyl 2-methylsulfonylbenzenesulfonate | 3-[3-({[(Z)-amino(imino)methyl]amino}oxy)propoxy]-5-methylphenyl 2-methylsulfonylbenzenesulfonate | CHEMBL37637
Type:
Small organic molecule
Emp. Form.:
C18H23N3O7S2
Mol. Mass.:
457.521
SMILES:
Cc1cc(OCCCONC(N)=N)cc(OS(=O)(=O)c2ccccc2S(C)(=O)=O)c1
Structure:
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