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Target
5-hydroxytryptamine receptor 6
Ligand
BDBM50334252
Substrate
n/a
Meas. Tech.
ChEMBL_2080058 (CHEMBL4735849)
Ki
4.0±n/a nM
Citation
 Staro?, J; Bugno, R; Pietru?, W; Sata?a, G; Mordalski, S; Warszycki, D; Hogendorf, A; Hogendorf, AS; Kalinowska-T?u?cik, J; Lenda, T; Pilarski, B; Bojarski, AJ Rationally designed N-phenylsulfonylindoles as a tool for the analysis of the non-basic 5-HT Eur J Med Chem 209:0 (2021) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 6
Synonyms:
5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46968.43
Organism:
Homo sapiens (Human)
Description:
P50406
Residue:
440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
  
Inhibitor
Name:
BDBM50334252
Synonyms:
3-(4-methylpiperazin-1-yl)-1-(phenylsulfonyl)-1H-indole | CHEMBL1642416
Type:
Small organic molecule
Emp. Form.:
C19H21N3O2S
Mol. Mass.:
355.454
SMILES:
CN1CCN(CC1)c1cn(c2ccccc12)S(=O)(=O)c1ccccc1
Structure:
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