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Target
RNA-directed RNA polymerase catalytic subunit
Ligand
BDBM50154375
Substrate
n/a
Meas. Tech.
ChEMBL_2080068 (CHEMBL4735859)
EC50
24000±n/a nM
Citation
 Massari, S; Bertagnin, C; Pismataro, MC; Donnadio, A; Nannetti, G; Felicetti, T; Di Bona, S; Nizi, MG; Tensi, L; Manfroni, G; Loza, MI; Sabatini, S; Cecchetti, V; Brea, J; Goracci, L; Loregian, A; Tabarrini, O Synthesis and characterization of 1,2,4-triazolo[1,5-a]pyrimidine-2-carboxamide-based compounds targeting the PA-PB1 interface of influenza A virus polymerase. Eur J Med Chem 209:0 (2021) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase catalytic subunit
Synonyms:
2.7.7.48 | PB1 | RDRP_I34A1
Type:
PROTEIN
Mol. Mass.:
86603.70
Organism:
Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)
Description:
ChEMBL_119393
Residue:
757
Sequence:
MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSEKGRWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHPGIFENSCIETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLTANESGRLIDFLKDVMESMKKEEMGITTHFQRKRRVRDNMTKKMITQRTIGKKKQRLNKRSYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYMTRNQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQIPAEMLASIDLKYFNDSTRKKIEKIRPLLIEGTASLSPGMMMGMFNMLSTVLGVSILNLGQKRYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLLGINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFEIKKLWEQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPFVSHKEIESMNNAVMMPAHGPAKNMEYDAVATTHSWIPKRNRSILNTSQRGVLEDEQMYQRCCNLFEKFFPSSSYRRPVGISSMVEAMVSRARIDARIDFESGRIKKEEFTEIMKICSTIEELRRQK
  
Inhibitor
Name:
BDBM50154375
Synonyms:
Adenosine receptor agonist, 16 | Ribavirin | Tribavirin | cid_37542 | med.21724, Compound 180
Type:
Small organic molecule
Emp. Form.:
C8H12N4O5
Mol. Mass.:
244.2047
SMILES:
NC(=O)c1ncn(n1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O |r|
Structure:
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