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Target
Histamine H3 receptor
Ligand
BDBM50562729
Substrate
n/a
Meas. Tech.
ChEMBL_2080122 (CHEMBL4735913)
IC50
0.520000±n/a nM
Citation
 Zhang, M; Tang, L; Jiang, L; Wei, J; Hu, Y; Sheng, R Identification of N-phenyl-3-methoxy-4-pyridinones as orally bioavailable H Eur J Med Chem 212:0 (2021) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50562729
Synonyms:
CHEMBL4748265
Type:
Small organic molecule
Emp. Form.:
C19H24N2O3
Mol. Mass.:
328.4055
SMILES:
COc1cn(ccc1=O)-c1ccc(OCCCN2CCCC2)cc1
Structure:
Search PDB for entries with ligand similarity: