Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50318633
Substrate
n/a
Meas. Tech.
ChEMBL_2080337 (CHEMBL4736128)
Ki
2370±n/a nM
Citation
 Vanda, D; Canale, V; Chaumont-Dubel, S; Kurczab, R; Sata?a, G; Koczurkiewicz-Adamczyk, P; Krawczyk, M; Pietru?, W; Blicharz, K; P?kala, E; Bojarski, AJ; Popik, P; Marin, P; Soural, M; Zajdel, P Imidazopyridine-Based 5-HT J Med Chem 64:1180-1196 (2021) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A
Type:
n/a
Mol. Mass.:
46122.49
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
422
Sequence:
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
  
Inhibitor
Name:
BDBM50318633
Synonyms:
3-benzenesulfonyl-8-piperazin-1-ylquinoline | CHEMBL1083390 | SB-742457
Type:
Small organic molecule
Emp. Form.:
C19H19N3O2S
Mol. Mass.:
353.438
SMILES:
O=S(=O)(c1ccccc1)c1cnc2c(cccc2c1)N1CCNCC1
Structure:
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