Reaction Details Report a problem with these data
Target
Sphingosine 1-phosphate receptor 1
Ligand
BDBM23163
Substrate
n/a
Meas. Tech.
ChEMBL_2080909 (CHEMBL4736700)
EC50
0.700000±n/a nM
Citation
 Gilmore, JL; Xiao, HY; Dhar, TGM; Yang, M; Xiao, Z; Yang, X; Taylor, TL; McIntyre, KW; Warrack, BM; Shi, H; Levesque, PC; Marino, AM; Cornelius, G; Mathur, A; Shen, DR; Pang, J; Cvijic, ME; Lehman-McKeeman, LD; Sun, H; Xie, J; Salter-Cid, L; Carter, PH; Dyckman, AJ Bicyclic Ligand-Biased Agonists of S1P J Med Chem 64:1454-1480 (2021) [PubMed]  Article 
Target
Name:
Sphingosine 1-phosphate receptor 1
Synonyms:
CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1
Type:
Enzyme
Mol. Mass.:
42836.02
Organism:
Homo sapiens (Human)
Description:
P21453
Residue:
382
Sequence:
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSHPQKDEGDNPETIMSSGNVNSSS
  
Inhibitor
Name:
BDBM23163
Synonyms:
CHEMBL114606 | FTY720-phosphate, rac-2 | {2-amino-3-hydroxy-2-[2-(4-octylphenyl)ethyl]propoxy}phosphonic acid
Type:
Small organic molecule
Emp. Form.:
C19H34NO5P
Mol. Mass.:
387.4507
SMILES:
CCCCCCCCc1ccc(CCC(N)(CO)COP(O)(O)=O)cc1
Structure:
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