Reaction Details Report a problem with these data
Target
Cyclin-C
Ligand
BDBM50073190
Substrate
n/a
Meas. Tech.
ChEMBL_2081913 (CHEMBL4737704)
Ki
9.0±n/a nM
Citation
 Yu, M; Teo, T; Yang, Y; Li, M; Long, Y; Philip, S; Noll, B; Heinemann, GK; Diab, S; Eldi, P; Mekonnen, L; Anshabo, AT; Rahaman, MH; Milne, R; Hayball, JD; Wang, S Potent and orally bioavailable CDK8 inhibitors: Design, synthesis, structure-activity relationship analysis and biological evaluation. Eur J Med Chem 214:0 (2021) [PubMed]  Article 
Target
Name:
Cyclin-C
Synonyms:
CCNC | CCNC_HUMAN | Cyclin C | SRB11 homolog | hSRB11
Type:
PROTEIN
Mol. Mass.:
33244.88
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107900
Residue:
283
Sequence:
MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS
  
Inhibitor
Name:
BDBM50073190
Synonyms:
CHEMBL3408213 | US11471446, Compound DBA-11
Type:
Small organic molecule
Emp. Form.:
C23H24ClN5O
Mol. Mass.:
421.923
SMILES:
Cn1cc(cn1)-c1ccc(cc1)-c1cncc(Cl)c1N1CCC2(CCNC2=O)CC1
Structure:
Search PDB for entries with ligand similarity: