Reaction Details Report a problem with these data
Target
Histamine H3 receptor
Ligand
BDBM50127610
Substrate
n/a
Meas. Tech.
ChEMBL_86758 (CHEMBL693567)
Ki
1.3±n/a nM
Citation
 Kazuta, Y; Hirano, K; Natsume, K; Yamada, S; Kimura, R; Matsumoto, S; Furuichi, K; Matsuda, A; Shuto, S Cyclopropane-based conformational restriction of histamine. (1S,2S)-2-(2-aminoethyl)-1-(1H-imidazol-4-yl)cyclopropane, a highly selective agonist for the histamine H3 receptor, having a cis-cyclopropane structure. J Med Chem 46:1980-8 (2003) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM50127610
Synonyms:
(1S,2S)-2-(2-aminoethyl)-1-(1H-imidazol-4-yl)cyclopropane | 2-[2-(1H-Imidazol-4-yl)-cyclopropyl]-ethylamine | CHEMBL60716
Type:
Small organic molecule
Emp. Form.:
C8H13N3
Mol. Mass.:
151.2089
SMILES:
NCC[C@@H]1C[C@@H]1c1cnc[nH]1
Structure:
Search PDB for entries with ligand similarity: