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Target
Cytochrome P450 4Z1
Ligand
BDBM50563463
Substrate
n/a
Meas. Tech.
ChEMBL_2082777 (CHEMBL4738568)
IC50
63±n/a nM
Citation
 Machalz, D; Li, H; Du, W; Sharma, S; Liu, S; Bureik, M; Wolber, G Discovery of a novel potent cytochrome P450 CYP4Z1 inhibitor. Eur J Med Chem 215:0 (2021) [PubMed]  Article 
Target
Name:
Cytochrome P450 4Z1
Synonyms:
1.14.14.1 | CP4Z1_HUMAN | CYP4Z1 | CYPIVZ1 | Cytochrome P450 4Z1
Type:
PROTEIN
Mol. Mass.:
59112.99
Organism:
Homo sapiens
Description:
ChEMBL_119125
Residue:
505
Sequence:
MEPSWLQELMAHPFLLLILLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPAHWFYGHKEFYPVKEFEVYHKLMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQDPKSAVSHKILESWVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQELHQFTEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAKSENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSITWEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAPDHSRPPQPVRQVVLKSKNGIHVFAKKVC
  
Inhibitor
Name:
BDBM50563463
Synonyms:
CHEMBL4800099
Type:
Small organic molecule
Emp. Form.:
C18H15N3O3
Mol. Mass.:
321.33
SMILES:
OC(=O)c1cccc(CNC(=O)c2ccc(cc2)-n2ccnc2)c1
Structure:
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