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Target
Homeodomain-interacting protein kinase 4
Ligand
BDBM50242737
Substrate
n/a
Meas. Tech.
ChEMBL_2083251 (CHEMBL4739042)
IC50
100±n/a nM
Citation
 N?mec, V; Maier, L; Berger, BT; Chaikuad, A; Drápela, S; Sou?ek, K; Knapp, S; Paruch, K Highly selective inhibitors of protein kinases CLK and HIPK with the furo[3,2-b]pyridine core. Eur J Med Chem 215:0 (2021) [PubMed]  Article 
Target
Name:
Homeodomain-interacting protein kinase 4
Synonyms:
HIPK4 | HIPK4_HUMAN
Type:
PROTEIN
Mol. Mass.:
69426.24
Organism:
Homo sapiens (Human)
Description:
ChEMBL_655821
Residue:
616
Sequence:
MSTIQSETDCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDPEEAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARLKELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPEILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFPDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFVSMQQLRSAHETTHYYQLSLRSYRLSLQVEGKPPTPVVAAEDGTPYYCLAEEKEAAGMGSVAGSSPFFREEKAPGMQRAIDQLDDLSLQEAGHGLWGETCTNAVSDMMVPLKAAITGHHVPDSGPEPILAFYSSRLAGRHKARKPPAGSKSDSNFSNLIRLSQVSPEDDRPCRGSSWEEGEHLGASAEPLAILQRDEDGPNIDNMTMEAERPDPELFDPSSCPGEWLSEPDCTLESVRGPRAQGLPPRRSHQHGPPRGATSFLQHVTGHH
  
Inhibitor
Name:
BDBM50242737
Synonyms:
(R,Z)-5-(2,6-dichlorobenzylsulfonyl)-3-((3,5-dimethyl-4-(2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl)-1H-pyrrol-2-yl)methylene)indolin-2-one | CHEMBL450786 | PHA-665752 | TCMDC-125885
Type:
Small organic molecule
Emp. Form.:
C32H34Cl2N4O4S
Mol. Mass.:
641.608
SMILES:
Cc1[nH]c(\C=C2/C(=O)Nc3ccc(cc23)S(=O)(=O)Cc2c(Cl)cccc2Cl)c(C)c1C(=O)N1CCC[C@@H]1CN1CCCC1 |r|
Structure:
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