Reaction Details Report a problem with these data
Target
Endothelin-1 receptor
Ligand
BDBM50127760
Substrate
n/a
Meas. Tech.
ChEBML_64198
Ki
2±n/a nM
Citation
 Lange, UE; Braje, WM; Amberg, W; Kettschau, G Solid-phase synthesis of endothelin receptor antagonists. Bioorg Med Chem Lett 13:1721-4 (2003) [PubMed]  Article 
Target
Name:
Endothelin-1 receptor
Synonyms:
EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48736.88
Organism:
Homo sapiens (Human)
Description:
P25101
Residue:
427
Sequence:
METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRSSHKDSMN
  
Inhibitor
Name:
BDBM50127760
Synonyms:
2-[4-(4-Ethoxy-phenyl)-6-methyl-pyrimidin-2-yloxy]-3,3-diphenyl-butyric acid | CHEMBL46311
Type:
Small organic molecule
Emp. Form.:
C29H28N2O4
Mol. Mass.:
468.5436
SMILES:
CCOc1ccc(cc1)-c1cc(C)nc(OC(C(O)=O)C(C)(c2ccccc2)c2ccccc2)n1
Structure:
Search PDB for entries with ligand similarity: