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Target
Free fatty acid receptor 1
Ligand
BDBM50204012
Substrate
n/a
Meas. Tech.
ChEMBL_2085012 (CHEMBL4766275)
EC50
1.000000±n/a nM
Citation
 Hamdouchi, C; Kahl, SD; Patel Lewis, A; Cardona, GR; Zink, RW; Chen, K; Eessalu, TE; Ficorilli, JV; Marcelo, MC; Otto, KA; Wilbur, KL; Lineswala, JP; Piper, JL; Coffey, DS; Sweetana, SA; Haas, JV; Brooks, DA; Pratt, EJ; Belin, RM; Deeg, MA; Ma, X; Cannady, EA; Johnson, JT; Yumibe, NP; Chen, Q; Maiti, P; Montrose-Rafizadeh, C; Chen, Y; Reifel Miller, A The Discovery, Preclinical, and Early Clinical Development of Potent and Selective GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus (LY2881835, LY2922083, and LY2922470). J Med Chem 59:10891-10916 (2016) [PubMed]  Article 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1_MOUSE | Ffar1 | Gpr40
Type:
PROTEIN
Mol. Mass.:
31818.80
Organism:
Mus musculus
Description:
ChEMBL_1454431
Residue:
300
Sequence:
MDLPPQLSFALYVSAFALGFPLNLLAIRGAVSHAKLRLTPSLVYTLHLGCSDLLLAITLPLKAVEALASGAWPLPLPFCPVFALAHFAPLYAGGGFLAALSAGRYLGAAFPFGYQAIRRPRYSWGVCVAIWALVLCHLGLALGLETSGSWLDNSTSSLGINIPVNGSPVCLEAWDPDSARPARLSFSILLFFLPLVITAFCYVGCLRALVRSGLSHKRKLRAAWVAGGALLTLLLCLGPYNASNVASFINPDLGGSWRKLGLITGAWSVVLNPLVTGYLGTGPGRGTICVTRTQRGTIQK
  
Inhibitor
Name:
BDBM50204012
Synonyms:
CHEMBL3955132
Type:
Small organic molecule
Emp. Form.:
C28H29NO4S
Mol. Mass.:
475.599
SMILES:
COc1cccc2CCCN(Cc3ccc(COc4ccc(cc4)[C@H](CC(O)=O)C#CC)s3)c12 |r|
Structure:
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