Reaction Details Report a problem with these data
Target
Prolyl hydroxylase EGLN3
Ligand
BDBM50563889
Substrate
n/a
Meas. Tech.
ChEMBL_2085191 (CHEMBL4766454)
IC50
14±n/a nM
Citation
 Debenham, JS; Madsen-Duggan, C; Clements, MJ; Walsh, TF; Kuethe, JT; Reibarkh, M; Salowe, SP; Sonatore, LM; Hajdu, R; Milligan, JA; Visco, DM; Zhou, D; Lingham, RB; Stickens, D; DeMartino, JA; Tong, X; Wolff, M; Pang, J; Miller, RR; Sherer, EC; Hale, JJ Discovery of N-[Bis(4-methoxyphenyl)methyl]-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1-3 (HIF PHD1-3) for the Treatment of Anemia. J Med Chem 59:11039-11049 (2016) [PubMed]  Article 
Target
Name:
Prolyl hydroxylase EGLN3
Synonyms:
EGLN3 | EGLN3_HUMAN | Egl nine homolog 3 (EGLIN3) | Egl nine homolog 3 (EGLN3)
Type:
Protein
Mol. Mass.:
27265.54
Organism:
Homo sapiens (Human)
Description:
Q9H6Z9
Residue:
239
Sequence:
MPLGHIMRLDLEKIALEYIVPCLHEVGFCYLDNFLGEVVGDCVLERVKQLHCTGALRDGQLAGPRAGVSKRHLRGDQITWIGGNEEGCEAISFLLSLIDRLVLYCGSRLGKYYVKERSKAMVACYPGNGTGYVRHVDNPNGDGRCITCIYYLNKNWDAKLHGGILRIFPEGKSFIADVEPIFDRLLFFWSDRRNPHEVQPSYATRYAMTVWYFDAEERAEAKKKFRNLTRKTESALTED
  
Inhibitor
Name:
BDBM50563889
Synonyms:
CHEMBL4783524
Type:
Small organic molecule
Emp. Form.:
C24H21N5O4
Mol. Mass.:
443.4546
SMILES:
COc1ccc(cc1)C(NC(=O)c1cnc(nc1O)-c1cccnn1)c1ccc(OC)cc1
Structure:
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