Reaction Details Report a problem with these data
Target
Insulin-like growth factor-binding protein 5
Ligand
BDBM50128456
Substrate
n/a
Meas. Tech.
ChEBML_90543
Ki
240±n/a nM
Citation
 Zhu, YF; Wang, XC; Connors, P; Wilcoxen, K; Gao, Y; Gross, R; Strack, N; Gross, T; McCarthy, JR; Xie, Q; Ling, N; Chen, C Quinoline-carboxylic acids are potent inhibitors that inhibit the binding of insulin-like growth factor (IGF) to IGF-binding proteins. Bioorg Med Chem Lett 13:1931-4 (2003) [PubMed]  Article 
Target
Name:
Insulin-like growth factor-binding protein 5
Synonyms:
IBP5 | IBP5_HUMAN | IGFBP5 | Insulin-like growth factor binding protein 5
Type:
PROTEIN
Mol. Mass.:
30581.07
Organism:
Homo sapiens (Human)
Description:
ChEMBL_90411
Residue:
272
Sequence:
MVLLTAVLLLLAAYAGPAQSLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYREQVKIERDSREHEEPTTSEMAEETYSPKIFRPKHTRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRIISAPEMRQESEQGPCRRHMEASLQELKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDGDFQCHTFDSSNVE
  
Inhibitor
Name:
BDBM50128456
Synonyms:
7-Chloro-4-(3,4-dihydroxy-benzyl)-6-hydroxy-quinoline-2-carboxylic acid | CHEMBL299912
Type:
Small organic molecule
Emp. Form.:
C17H12ClNO5
Mol. Mass.:
345.734
SMILES:
OC(=O)c1cc(Cc2ccc(O)c(O)c2)c2cc(O)c(Cl)cc2n1
Structure:
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