Reaction Details Report a problem with these data
Target
TGF-beta receptor type-1
Ligand
BDBM50564600
Substrate
n/a
Meas. Tech.
ChEMBL_2088444 (CHEMBL4769707)
IC50
>10000±n/a nM
Citation
 Xu, G; Zhang, Y; Wang, H; Guo, Z; Wang, X; Li, X; Chang, S; Sun, T; Yu, Z; Xu, T; Zhao, L; Wang, Y; Yu, W Synthesis and biological evaluation of 4-(pyridin-4-oxy)-3-(3,3-difluorocyclobutyl)-pyrazole derivatives as novel potent transforming growth factor-? type 1 receptor inhibitors. Eur J Med Chem 198:0 (2020) [PubMed]  Article 
Target
Name:
TGF-beta receptor type-1
Synonyms:
2.7.11.30 | ALK5 | AU017197 | ESK2 | TGF-beta receptor type I | TGF-beta receptor type-1 | TGFR-1 | TGFR1_MOUSE | TbetaR-I | Tgfbr1 | Transforming growth factor-beta receptor type I
Type:
n/a
Mol. Mass.:
56186.39
Organism:
Mus musculus
Description:
n/a
Residue:
503
Sequence:
MEAAAAAPRRPQLLIVLVAAATLLPGAKALQCFCHLCTKDNFTCETDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGAVTTTYCCNQDHCNKIELPTTGPFSEKQSAGLGPVELAAVIAGPVCFVCIALMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
  
Inhibitor
Name:
BDBM50564600
Synonyms:
CHEMBL4784607
Type:
Small organic molecule
Emp. Form.:
C24H26N6O3
Mol. Mass.:
446.5016
SMILES:
Cc1noc(C)c1-c1nn(cc1Oc1ccnc(Nc2ccnc(c2)C(C)(C)O)c1)C1CC1 |(64.58,-25.86,;64.58,-24.33,;63.33,-23.42,;63.81,-21.96,;65.34,-21.96,;66.24,-20.72,;65.82,-23.42,;67.28,-23.89,;68.53,-22.98,;69.77,-23.89,;69.29,-25.35,;67.75,-25.35,;66.85,-26.6,;67.47,-28.01,;69,-28.17,;69.63,-29.57,;68.72,-30.83,;67.19,-30.67,;66.27,-31.91,;64.74,-31.75,;64.13,-30.34,;62.59,-30.18,;61.68,-31.42,;62.32,-32.83,;63.85,-32.99,;61.41,-34.08,;62.74,-34.85,;61.4,-35.62,;59.88,-33.93,;66.56,-29.26,;71.24,-23.41,;72.75,-23.73,;72.28,-22.27,)|
Structure:
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